Publications by authors named "S Lingl"
Article Synopsis
- - The study investigates the effects of the dopamine analogue CA140 on Alzheimer's disease pathology and related cognitive functions by administering it to both wild-type and 5xFAD mice models over a period of 10 to 17 days.
- - Results showed that CA140 significantly reduced Alzheimer-related markers such as Aβ/tau fibrillation, plaque numbers, and neuroinflammation, possibly via the inhibition of NLRP3 activation and regulation of key astrocyte and microglial markers.
- - Additionally, CA140 administration improved long-term memory and synaptic function, indicating its potential to modulate cognitive deficits in Alzheimer's through dopamine D1 receptor signaling pathways.
Bringing optical microscopy to the shortest possible length and time scales has been a long-sought goal, connecting nanoscopic elementary dynamics with the macroscopic functionalities of condensed matter. Super-resolution microscopy has circumvented the far-field diffraction limit by harnessing optical nonlinearities. By exploiting linear interaction with tip-confined evanescent light fields, near-field microscopy has reached even higher resolution, prompting a vibrant research field by exploring the nanocosm in motion.
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