Determining patient activity goals and their fulfillment following total knee arthroplasty: Findings from the prospective, observational SuPeR Knee study.

Background: Dissatisfaction with Total Knee Arthroplasty (TKA) surgical outcomes remains between 10-20% and is associated with higher levels of societal costs. Expectations regarding post-surgical outcomes is considered as one of the major factors influencing satisfaction, however, there are no standardised methods for assessing patient's expectations regarding activities to be achieved following surgery.

Objectives: The aims of this study were to identify patient expectations relating to activities of importance following TKA and to describe goal fulfillment at 3 months post-TKA.

Pollination efficiency and the evolution of sex allocation - diminishing returns matter.

Immobility of flowering plants requires them to engage pollen vectors to outcross, introducing considerable inefficiency in the conversion of pollen production into sired seeds. Whether inefficiencies influence the evolution of the relative resource allocation to female and male functions has been debated for more than 40 years. Whereas early models suggested no effect, negative interspecific relations of mean pollen production and pollen : ovule ratios to the proportion of removed pollen that is exported to stigmas (pollen-transfer efficiency) indicate otherwise.

REVEAL-CP: Selective Screening of Pediatric Patients for Aromatic L-Amino Acid Decarboxylase Deficiency with a Guthrie Card and Structural Modeling of One Index Case.

The main objective of this prospective, multicenter study (REVEAL-CP) was to test children with cerebral palsy-like signs and symptoms for raised 3--methyldopa (3-OMD) blood levels, a biomarker for aromatic L-amino acid decarboxylase deficiency (AADCd). A secondary objective was to characterize the molecular basis for the defective aromatic L-amino acid decarboxylase (AADC) gene product. Patients were identified in pediatric secondary and tertiary care hospitals through database searches and personal communication.

Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.

Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.

Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.

Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).

From Sevagram to National Health Policy: Dr. Sushila Nayar's Contributions to Rural Healthcare and Medical Education in India.

Dr. Sushila Nayar (1914-2001) was a pioneering figure in Indian public health whose work spanned from grassroots initiatives to national policy formation. This review article traces Dr.