Publications by authors named "S Lindsey"
Importance: Enhanced breast cancer screening with magnetic resonance imaging (MRI) is recommended to women with elevated risk of breast cancer, yet uptake of screening remains unclear after genetic testing.
Objective: To evaluate uptake of MRI after genetic results disclosure and counseling.
Design, Setting, And Participants: This multicenter cohort study was conducted at the University of Southern California Norris Cancer Hospital, the Los Angeles General Medical Center, and the Stanford University Cancer Institute.
Article Synopsis
- * A study identified a specific genetic variation at Chr6:31373718C>G that is associated with increased CRC risk, particularly in the younger population, with stronger odds for EOCRC compared to older adults.
- * Analysis showed that individuals carrying the minor G allele have reduced expression of the immune-related MICA gene and lower levels of Natural Killer (NK) cell infiltration in tumors, suggesting a link between this genetic variation and tumor immune response.
Article Synopsis
- Testosterone (T) and 17β-estradiol (E2) are crucial hormones produced in both males and females, impacting metabolic health significantly.
- As these hormones decline with age, individuals may experience metabolic dysfunction, increasing the risk of degenerative diseases.
- Both hormones offer important benefits for metabolic functions, including bone health, insulin sensitivity, and immune responses, underscoring the potential advantages of managing their levels in aging populations.
Article Synopsis
- Preeclampsia is a serious condition during pregnancy that causes high blood pressure and heart problems for both mothers and their babies.
- Scientists tested a drug called G-1 to see if it could help with these issues in a rat model of preeclampsia.
- The results showed that G-1 lowered blood pressure and improved heart function, while another drug only lowered blood pressure without helping the heart.
What Is This Summary About?: Researchers wanted to study whether the research drug zanidatamab could help people with a type of cancer called biliary tract cancer. In some people, biliary tract cancer cells make extra copies of a gene called HER2 (also called ERBB2). This is known as being HER2-amplified.
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