Publications by authors named "S Lindenberg"
Purpose: Determine rates of progression of incomplete retinal pigment epithelium and outer retinal atrophy (iRORA) to complete retinal pigment epithelium and outer retinal atrophy (cRORA) and rates of progression of drusen to iRORA/cRORA in eyes with geographic atrophy (GA) treated with avacincaptad pegol (ACP).
Methods: Post hoc analysis of the GATHER1 prospective, randomized, double-masked Phase II/III study that evaluated ACP 2 mg vs. sham.
Article Synopsis
- Limited annotated datasets for 3D biomedical imaging make it challenging to train machine learning models for accurate disease prediction.
- The SLIViT model, pre-trained on 2D scans, effectively predicts disease-risk factors by processing 3D scans into 2D images and integrating their features.
- SLIViT outperformed existing models in various learning tasks and matched the accuracy of trained specialists, potentially saving time and costs in clinical settings.
Objective: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands activate the AhR signaling axis, whereas AhR activation is negatively regulated by the AhR repressor (AhRR). While AhR-deficient mice are known to be resistant to diet-induced obesity (DIO), the influence of the AhRR on DIO has not been assessed so far.
View Article and Find Full Text PDFBackground: Subretinal hyperreflective material (SHRM) is a significant biomarker for poor visual outcomes in neovascular age-related macular degeneration (nAMD); however, its relationship with fibrosis and atrophy is not well understood. This study aims to evaluate the relationship between SHRM, atrophy, and fibrosis in eyes receiving antivascular endothelial growth factor therapy for nAMD.
Methods: Post-hoc analysis of the 65 patients enrolled in the SEVEN-UP study, a multicenter cross-sectional study of patients originally enrolled in the ANCHOR and MARINA trials of ranibizumab.
Purpose: This study aims to define the characteristics of acquired vitelliform lesions (AVLs) in patients with intermediate age-related macular degeneration (iAMD).
Design: Retrospective, observational, cross sectional study.
Subjects: This study included 217 eyes with AVLs associated with iAMD, and an equivalent number of control patients.