Publications by authors named "S Lindemann"
M6495 is a first-in-class NANOBODY molecule and an inhibitor of ADAMTS-5, with the potential to be a disease modifying osteoarthritis drug. In order to investigate the PK/PD (pharmacokinetic and pharmacodynamic) properties of M6495, a single dose study was performed in cynomolgus monkeys with doses up to 6 mg/kg, with the goal of understanding the PK/PD properties of M6495. The neo-epitope ARGS (Alanine-Arginine-Glycine-Serine) generated by cleavage of aggrecan by ADAMTS-5 was used as a target-engagement biomarker.
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- The XENONnT dark matter experiment successfully measured nuclear recoils from solar ^{8}B neutrinos, marking a significant advancement in neutrino detection technology.
- Using a two-phase time projection chamber with a 5.9 t liquid xenon target, the experiment produced 37 observed events, which surpassed the expected background events, indicating a notable signal.
- The results provide a measured solar neutrino flux consistent with previous studies and confirm the neutrino cross section predictions aligned with the Standard Model, showcasing the effectiveness of dark matter detectors in neutrino research.
Background: Previous research demonstrates that adopting, abandoning, and re-adopting (i.e., cycling) a healthy dietary pattern (HDP) improved, reverted, and re-improved cardiovascular disease (CVD) risk factors.
View Article and Find Full Text PDFIn vitro fecal microbiota modulation properties of pectin and xyloglucan from hazelnut (Corylus avellana L.) skin, an industrial byproduct, and their incorporation into biscuit formula.
Int J Biol Macromol
November 2024
The aim of this study was to extract water-soluble dietary fibers (WSDF), pectin (PEC), and xyloglucan (XG) from hazelnut skin and to determine their impacts on colonic microbiota and metabolic function. WSDF, PEC, and XG were extracted by water, acid, and alkali treatments, respectively. Monosaccharide analysis revealed WSDF and PEC were dominated by uronic acids, while the XG was found to contain xyloglucan- and pectin-associated sugars.
View Article and Find Full Text PDFThe multi-staged XENON program at INFN Laboratori Nazionali del Gran Sasso aims to detect dark matter with two-phase liquid xenon time projection chambers of increasing size and sensitivity. The XENONnT experiment is the latest detector in the program, planned to be an upgrade of its predecessor XENON1T. It features an active target of 5.
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