Case Report: The potential association with polyglandular autoimmune syndrome in a dog following long-term oclacitinib therapy.

A 12-year-old spayed female Maltese dog had been receiving oclacitinib, a Janus kinase (JAK) inhibitor, for 7 years to manage chronic pruritus due to atopic dermatitis. During this treatment, the dog was diagnosed with primary hypoadrenocorticism and hypothyroidism based on history, physical examination, and hormonal analysis. This case was initially suspected to be polyglandular autoimmune syndrome (PAS) based on long-term treatment of oclacitinib.

The effect of social determinants of health on patient outcomes in acute trauma: A systematic review.

Introduction: Social determinants of health (SDoH) may mediate disparities, but their effect on outcomes after trauma is not well known. The purpose of this review is to improve existing gaps of knowledge for a broad range of SDoH and trauma-related outcomes.

Methods: This was a systematic search to identify studies that evaluated the effect of race, insurance status, socioeconomic status (SES), health literacy, and community deprivation on inpatient mortality, morbidity, and post-discharge health care utilization in diverse trauma populations ≥16 years.

Regulatory T Cell Metabolism: A Promising Therapeutic Target for Cancer Treatment?

Regulatory T (Treg) cells are essential for maintaining immune homeostasis by suppressing excessive immune responses. In the context of cancer, however, Tregs promote immune evasion and tumor progression, particularly through their unique adaptations within the tumor microenvironment (TME). Recent research has emphasized how metabolic characteristics shape Treg activation, migration, and immunosuppressive function, revealing the impact of metabolic pathways on Treg fitness in homeostasis and within the TME.

A Prospective, Multicenter, Randomized, Noninferiority Trial of Stopad Versus Tachosil for Hemostasis After Liver Resection.

Background: Hemostatic products are widely used to control bleeding in hepatic resections. Stopad is a pad-type hemostatic agent containing carboxymethyl chitosan and recombinant thrombin-like hemocoagulase.

Methods: We conducted a prospective, multicenter, randomized, noninferiority study of Stopad vs.