Improved Control of Triple-Negative Breast Cancer Tumor and Metastasis with a pH-Sensitive Hyaluronic Acid Nanocarrier for Doxorubicin Delivery.

Polymer based nanoformulations offer substantial prospects for efficacious chemotherapy delivery. Here, we developed a pH-responsive polymeric nanoparticle based on acidosis-triggered breakdown of boronic ester linkers. A biocompatible hyaluronic acid (HA) matrix served as a substrate for carrying a doxorubicin (DOX) prodrug which also possesses natural affinity for CD44 cells.

Outcomes of Acute Kidney Injury After Pediatric Liver Transplantation: A 1-Year Follow-Up.

Background: Postoperative acute kidney injury (AKI) and chronic kidney disease (CKD) following pediatric liver transplantation (PLT) have not been comprehensively studied. This study aimed to evaluate the correlation between AKI and both 1-year CKD and mortality.

Methods: This retrospective study included 132 children aged between 3 months and 12 years who underwent PLT between 2017 and 2021.

Comparison of clinical outcomes of bilateral and unilateral unicompartmental knee arthroplasty for the treatment of knee osteoarthritis.

The risks and benefits associated with simultaneous bilateral unicompartmental knee arthroplasty (UKA) continue to engender contentious debate. The aim of this study was to compare the clinical outcomes of simultaneous bilateral and unilateral UKA. A retrospective review was performed between 2019 and 2022 on 280 patients (130 simultaneous bilateral vs.

Fractional order system identification using a joint multi-innovation fractional gradient descent algorithm.

This paper proposes a joint multi-innovation fractional gradient descent identification algorithm for fractional order systems. First, the flexibility of fractional calculus is leveraged to design a joint fractional gradient descent algorithm capable of estimating system parameters and unknown orders. The estimated system parameters are used as the initial conditions to identify the unknown order, and the identified order is used as the update conditions for the system parameters.

Overview of Gas-Generating-Reaction-Based Immunoassays.

Point-of-care (POC) immunoassays have become convincing alternatives to traditional immunosensing methods for the sensitive and real-time detection of targets. Immunoassays based on gas-generating reactions were recently developed and have been used in various fields due to their advantages, such as rapid measurement, direct reading, simple operation, and low cost. Enzymes or nanoparticles modified with antibodies can effectively catalyze gas-generating reactions and convert immunorecognition events into gas pressure signals, which can be easily recorded by multifunctional portable devices.