Publications by authors named "S Levet"
Article Synopsis
- The study analyzed changes in the incidence and causes of maternal deaths due to obstetric hemorrhage in France from 2001 to 2015, focusing on the impact of national guidelines implemented in 2004 and updated in 2014.
- Findings revealed a significant drop in the maternal mortality ratio (MMR) from 2.3 to 0.8 per 100,000 livebirths, with a notable decrease in deaths from uterine atony.
- Despite improved clinical care, 88% of maternal deaths from hemorrhage were still considered preventable, highlighting areas needing further improvement in diagnosis and surgical management.
Technical notes surgical treatment of a ruptured interstitial pregnancy.
J Gynecol Obstet Hum Reprod
September 2022
Non-tubal ectopic pregnancies represent fewer than 10% of all ectopic pregnancies. However, they are associated with a high rate of mortality due to late diagnosis and uterine horn rupture which requires radical emergency surgical management. Cornuectomy via laparoscopy is a treatment of choice.
View Article and Find Full Text PDFHuman Endogenous Retrovirus W Envelope (HERV-W ENV) mRNA or protein can be found in peripheral blood mononuclear cells (PBMCs) and exocrine pancreas of patients with type 1 diabetes (T1D). Further, previous observations have shown an association between enteroviral infection and development of T1D; specifically, coxsackievirus-B (CV-B) has been detected in the blood and pancreas of patients with T1D. Notably, viruses can activate HERV-W expression.
View Article and Find Full Text PDFPurpose Of The Review: The aim of this review is to discuss recent data pointing at an involvement of human endogenous retroviruses (HERVs) in type 1 diabetes (T1D) onset and progression.
Recent Findings: The envelope protein of HERV-W family, named HERV-W-Env, was detected in pancreata from T1D patients and was shown to display pro-inflammatory properties and direct toxicity toward pancreatic beta cells. The etiopathogenesis of T1D remains elusive, even if conventional environmental viral infections have been recurrently involved.
We describe a newly identified therapeutic target for type 1 diabetes (T1D): an envelope protein of endogenous retroviral origin, human endogenous retrovirus W envelope (HERV-W-Env). HERV-W-Env was found to be detected in the blood of ~60% of patients with T1D and is expressed in acinar pancreatic cells of 75% of patients with T1D at post mortem examination. Preclinical experiments showed that this protein displays direct cytotoxicity on human β-islet cells.
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