Publications by authors named "S Letho"
Article Synopsis
- Bovine tuberculosis (bTB) is a chronic disease in cattle that threatens public health and causes economic loss, being less common in developed countries but still prevalent in regions like Africa, Asia, and the Middle East.
- In this study in eastern Bhutan, researchers used a sampling method to test 971 cattle for bTB, finding a seroprevalence of 2.57%, but a true prevalence of only 0.91% after adjustments.
- The study concluded that while no significant risk factors were identified, more comprehensive testing and sampling are needed to better understand and control bTB in Bhutanese cattle populations.
Article Synopsis
- Rabies causes about 59,000 deaths globally each year, making rapid diagnosis crucial for quick response and treatment.
- This study tested 179 brain samples from various rabies-suspected animals using a rapid test kit and a standard fluorescent antibody test, evaluating the accuracy of the rapid test.
- The rapid kit showed high sensitivity (92%) and perfect specificity (100%), indicating it can effectively confirm rabies cases and support surveillance efforts, especially in areas with limited resources.*
Background: Rabies is a highly fatal disease transmitted through the bite of a rabid animal. Human deaths can be prevented by prompt administering of rabies vaccine and rabies immunoglobulin following the exposure. An assessment of community knowledge, awareness and practices on rabies is important during outbreak to understand their preparedness and target educational messages and response activities by the rapid response team.
View Article and Find Full Text PDFThe excretory-secretory products of exsheathed third-stage larvae of Trichostrongylus colubriformis conferred some protection to guinea pigs against homologous challenge. A glycoprotein with an apparent molecular mass of approximately 94 kDa was the dominant immunogen in post-exsheathment products. Immunoblots revealed IgG antibodies to this glycoprotein in sera from multiply-infected guinea pigs and some sheep, and in sera of guinea pigs after three truncated infections which had been restricted by anthelmintic treatments to development of the third parasitic stage.
View Article and Find Full Text PDFThe detergent-soluble fraction from Trichostrongylus colubriformis third-stage larvae contained a simple set of antigens, one of which (molecular weight 41,000) induced 43-51% protection in guinea pigs following immunization. Isolation and partial amino acid sequence analysis of this protective antigen showed it was parasite tropomyosin.
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