Publications by authors named "S Leiz"
Long-term follow-up MR imaging in children with transverse myelitis.
Mult Scler Relat Disord
December 2024
Article Synopsis
- The study investigates how lesions in children with transverse myelitis (TM) resolve over time, focusing on different related diseases: MOG-antibody associated disorders (MOGAD), multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and double seronegative TM.
- A total of 78 children from various medical centers were assessed, and a grading system was used to measure the resolution of lesions over time.
- Results showed that MOGAD had the fastest and most complete resolution of lesions, followed by double seronegative TM, MS, and NMOSD, with none of the NMOSD patients achieving complete resolution during the observation period.
Article Synopsis
- Nine out of 19 genes that code for GABA receptor subunits are linked to disorders associated with seizures and developmental issues.
- The study identified three new de novo missense variants in the GABRA4 gene in patients with epilepsy and various neurodevelopmental problems, highlighting a connection between these genetic changes and neurological symptoms.
- Molecular dynamics simulations showed that the mutated GABRA4 subunits behave differently than the normal ones, supporting the role of this gene in causing a range of neurological conditions.
Autoantibody status, neuroradiological and clinical findings in children with acute cerebellitis.
Eur J Paediatr Neurol
November 2023
Background: Acute cerebellitis (AC) in children and adolescents is an inflammatory disease of the cerebellum due to viral or bacterial infections but also autoimmune-mediated processes.
Objective: To investigate the frequency of autoantibodies in serum and CSF as well as the neuroradiological features in children with AC.
Material And Methods: Children presenting with symptoms suggestive of AC defined as acute/subacute onset of cerebellar symptoms and MRI evidence of cerebellar inflammation or additional CSF pleocytosis, positive oligoclonal bands (OCBs), and/or presence of autoantibodies in case of negative cerebellar MRI.
Article Synopsis
- ADEM is a common pediatric condition linked to MOG antibodies that results in brain growth impairment, but its specific impact from MOG antibodies was previously unclear.
- The study included 62 MRI scans from 24 ADEM patients, revealing that both MOG-positive and negative patients initially had lower brain volumes compared to healthy controls.
- Long-term results showed that MOG-negative patients experienced greater brain volume loss than MOG-positive ones, and relapsing MOG-positive patients also faced additional volume reductions.