Publications by authors named "S Ledochowski"
The morbidity of aneurysmal subarachnoid hemorrhage (aSAH) remains high, particularly because of secondary cerebral lesions that significantly aggravate the primary lesions. The main type of secondary lesions is delayed cerebral ischemia (DCI), in which platelets (PLT) appear to play a key role. Mean platelet volume (MPV) is an indirect marker of platelet activation.
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- Severe thrombotic antiphospholipid syndrome (APS) significantly affects critical organs and has not been thoroughly studied in ICU patients, particularly regarding hematological issues.
- A retrospective study in France tracked 134 APS patients in ICUs, revealing high rates of anemia (95%) and thrombocytopenia (93%), with low platelet counts linked to increased mortality.
- The findings highlight the importance of understanding the causes of thrombocytopenia in APS patients, as conditions like thrombotic microangiopathy (TMA), heparin-induced thrombocytopenia (HIT), and disseminated intravascular coagulation (DIC) are prevalent in this population.
Article Synopsis
- The study investigates fluid intake in ICU patients at risk of negative outcomes due to excessive fluid balance, highlighting the need for fluid optimization beyond traditional resuscitation.
- Conducted across multiple ICUs in France and Spain, it recorded the types and volumes of fluids administered to patients needing vasopressors or invasive ventilation over a 24-hour period.
- Results indicate that only 36% of the total fluid volume was essential for body fluid homeostasis, with significant variations in fluid administration based on the specific ICU, suggesting a strong center effect on fluid management practices.
Article Synopsis
- * The study analyzed data from 136 APS patients from January 2000 to September 2018, finding that over half (53%) had new cardiac problems, with many showing reduced heart function and elevated heart-related biomarkers.
- * Although cardiac involvement in these patients slightly increased the risk of mortality, most patients' heart function improved after one year, highlighting the need for better recognition and management of cardiac complications in APS.