Toxicity assessment of DMSO extracts of environmental aged beached plastics using human cell lines.

Plastic products contain complex mixtures of chemical compounds that are incorporated into polymers to improve material properties. Besides the intentional chemical additives, other compounds including residual monomers and non-intentionnaly added substances (NIAS) as well as sorbed pollutants are usually also present in aged plastic. Since most of these substances are only loosely bound to the polymer via non-covalently interactions, i.

Tripolar Bolalipids as Key Components of Sustained-Release Drug Delivery Systems.

Controlling passive diffusion through an amphiphilic membrane is a key factor for the development of future smart generations of drug delivery systems. It also plays a crucial role in understanding fundamental biological systems through the design of new artificial cell models. We report herein a new concept of bolalipids designed as key components for the control of the membrane's permeability.

Nanoscale Chemical Imaging of Amyloid Fibrils in Water Using Total-Internal-Reflection Tip-Enhanced Raman Spectroscopy.

Total-internal-reflection tip-enhanced Raman spectroscopy (TIR-TERS) imaging of amyloid-β (Aβ-L34T) fibrils is performed with nanoscale spatial resolution in water, using TERS tips fabricated by bipolar electrodeposition. Ideal experimental parameters are corroborated by both theoretical simulations and TIR-TERS measurements. TIR-TERS imaging reveals the predominant parallel β-sheet secondary structure of Aβ-L34T fibrils as well as the nanoscale spatial distribution of tyrosine, histidine, and phenylalanine aromatic amino acids.

Short term plasticity at hippocampal mossy fiber synapses.

Short-term synaptic plasticity refers to the regulation of synapses by their past activity on time scales of milliseconds to minutes. Hippocampal mossy fiber synapses onto CA3 pyramidal cells (Mf-CA3 synapses) are endowed with remarkable forms of short-term synaptic plasticity expressed as facilitation of synaptic release by a factor of up to ten-fold. Three main forms of short-term plasticity are distinguished: 1) Frequency facilitation, which includes low frequency facilitation and train facilitation, operating in the range of tens of milliseconds to several seconds; 2) Post-tetanic potentiation triggered by trains of high frequency stimulation, which lasts several minutes; 3) Finally, depolarization-induced potentiation of excitation, based on retrograde signaling, with an onset and offset of several minutes.

TORPP - Turtles, One Health Research & Plastic Pollution: A multidisciplinary consortium to evaluate the environmental and health impact of Micro/NanoPlastics (MNPs) pollution.

Although the World Health Organization characterizes a One Health concern as one in which there is the capability to incorporate numerous disciplines to tackle health challenges threatening humans, animals and ecosystems, scientific efforts frequently remain compartmentalized. Here we report an original consortium, TORPP, spanning 16 disciplines, focused on Micro/NanoPlastics (MNPs) pollution as a One Health concern. Whereas the MNP topic has been largely studied in marine ecology, research effort remains scarce in human medicine.