Blood metabolomic profiling reveals new targets in the management of psychological symptoms associated with severe alcohol use disorder.

Background: Alcohol use disorder (AUD) is a global health problem with limited therapeutic options. The biochemical mechanisms that lead to this disorder are not yet fully understood, and in this respect, metabolomics represents a promising approach to decipher metabolic events related to AUD. The plasma metabolome contains a plethora of bioactive molecules that reflects the functional changes in host metabolism but also the impact of the gut microbiome and nutritional habits.

Genomic insights into epidemic plasmids carrying and genes in from Lebanese broiler production.

Background: In a previous nationwide survey in the Lebanese broiler production, multidrug-resistant CTX-M-producing were found to carry the mobile colistin resistance gene .

Objectives: To investigate the mobile genetic supports responsible for the spread of these resistance genes among in healthy broilers in Lebanon.

Methods: Thirty-three and - positive of various sequence types from 17 broilers farms were subjected to conjugation assays.

Cerebral small vessel disease and glymphatic system dysfunction in multiple sclerosis: A narrative review.

As the multiple sclerosis (MS) population ages, the prevalence of vascular comorbidities increases, potentially accelerating disease progression and brain atrophy. Recent studies highlight the prevalence of cerebral small vessel disease (CSVD) in MS, suggesting a potential link between vascular comorbidities and accelerated disability. CSVD affects the brain's small vessels, often leading to identifiable markers on MRI such as enlarged perivascular spaces (EPVS).

Involvement of the gut microbiome-brain axis in alcohol use disorder.

The human intestine is colonized by a variety of microorganisms that influence the immune system, the metabolic response, and the nervous system, with consequences for brain function and behavior. Unbalance in this microbial ecosystem has been shown to be associated with psychiatric disorders, and altered gut microbiome composition related to bacteria, viruses, and fungi has been well established in patients with alcohol use disorder. This review describes the gut microbiome-brain communication pathways, including the ones related to the vagus nerve, the inflammatory cytokines, and the gut-derived metabolites.