Publications by authors named "S Le Guellec"
Article Synopsis
- Anatomical 3D-printed nasal casts are important for studying how drugs are delivered inside the nose and provide unique preclinical data not available from animal studies.
- The study analyzed CT scans from 98 patients, revealing anatomical differences in the nasal cavity and identifying three distinct nasal geometry groups, leading to the creation of representative 3D models.
- The research demonstrated that these anatomical variations significantly impact how well different medical devices deliver drugs, especially with nasal sprays and nebulizers, highlighting the need for diverse models to assess drug effectiveness in different populations.
Measles virus is one of the most contagious airborne human viruses which keeps causing outbreaks in numerous countries over the world despite the existence of an efficient vaccine. Fusion inhibitory lipopeptides were shown to inhibit viral entry into target cells, and their adequate administration into the respiratory tract may provide a novel preventive approach against airborne infections. Aerosol delivery presents the best administration route to deliver such preventive compounds to the upper and lower respiratory tract.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted on the genomic profiles of uterine smooth muscle tumors, focusing on two types: fumarate hydratase deficient leiomyomas and leiomyomas with bizarre nuclei, to understand their relationship with clinical outcomes.
- All patients in the study were alive without disease after an average follow-up of 87.3 months, leading to the conclusion that certain genomic indices (GI) were not reliable indicators of malignancy in these tumor types.
- The research identified three groups of tumors based on genomic alterations and their associated GIs, suggesting that a GI less than 10 indicates benignity, while a GI greater than 10 does not necessarily indicate malignancy, offering a new diagnostic approach for these tumors
Non-Human Primates (NHPs) are particularly relevant for preclinical studies during the development of inhaled biologics. However, aerosol inhalation in NHPs is difficult to evaluate due to a low lung deposition fraction and high variability. The objective of this study was to evaluate the influence of mesh nebulizer parameters to improve lung deposition in macaques.
View Article and Find Full Text PDF[Diagnosis of uterine sarcomas and rare uterine mesenchymal tumours with malignant potential. Guidelines of the French Sarcoma Group and Rare Gynaecological Tumours].
Bull Cancer
January 2024
Article Synopsis
- The classification of uterine sarcomas is evolving with the discovery of new types linked to specific genetic changes, categorizing them into complex genomic and simple genomic sarcomas.
- The most common types include leiomyosarcomas and endometrial stromal sarcomas, with various histological subtypes that have differing degrees of aggression.
- Recent advances in molecular diagnostics and targeted therapies are enhancing the identification and treatment strategies for these tumors.