Publications by authors named "S Layec"
The promising next-generation probiotic Faecalibacterium prausnitzii is one of the most abundant acetate-consuming, butyrate-producing bacteria in the healthy human gut. Yet, little is known about how acetate availability affects this bacterium's gene expression strategies. Here, we investigated the effect of acetate on temporal changes in the transcriptome of F.
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- The study aimed to assess the incidence and severity of COVID-19 among patients receiving home parenteral nutrition (HPN) for chronic intestinal failure over a year-long observation period from March 2020 to March 2021.
- Out of 4680 patients from 68 centers across 23 countries, the cumulative incidence of COVID-19 infection was 9.6%, with 55.1% of patients providing COVID-related data, revealing varying rates of infection severity.
- Results indicated a higher incidence and severity of infection among deceased patients, and significant proportions of the cohort were unvaccinated or had unknown vaccination statuses; 42.8% of deaths in infected individuals were attributed to COVID-19.
Although central venous catheter (CVC)-related thrombosis (CRT) is a severe complication of home parenteral nutrition (HPN), the amount and quality of data in the diagnosis and management of CRT remain low. We aimed to describe current practices regarding CVC management in French adult and pediatric HPN centers, with a focus on CVC obstruction and CRT. Current practices regarding CVC management in patients on HPN were collected by an online-based cross-sectional survey sent to expert physicians of French HPN centers.
View Article and Find Full Text PDFThe expanding knowledge on the systemic influence of the human microbiome suggests that fecal samples are underexploited sources of new beneficial strains for extra-intestinal health. We have recently shown that acetate, a main circulating microbiota-derived molecule, reduces the deleterious effects of pulmonary and enteric serovar Typhimurium bacterial post-influenza superinfections. Considering the beneficial and broad effects of acetate, we intended to isolate a commensal strain, producing acetate and potentially exploitable in the context of respiratory infections.
View Article and Find Full Text PDFBackground: High-output double enterostomies (DESs) result in sodium and fluid loss responsible for frequent episodes of dehydration and hospitalizations. Hydration by enteroclysis (HE) is an alternative to parenteral hydration when the small bowel, or the downstream colon, is accessible and functional.
Methods: A retrospective analysis was conducted on all consecutive patients admitted in our institution with high-output (≥1200 ml per 24 h) DES and access to downstream intestine (including colon), who were treated by enteroclysis between 2015 and 2019.