The Efficacy of Risk Factor Modification Compared to NAD Repletion in Diastolic Heart Failure.

Heart failure (HF) with left ventricular diastolic dysfunction is a growing global concern. This study evaluated myocardial oxidized nicotinamide adenine dinucleotide (NAD) levels in human systolic and diastolic HF and in a murine model of HF with preserved ejection fraction, exploring NAD repletion as therapy. We quantified myocardial NAD and nicotinamide phosphoribosyltransferase levels, assessing restoration with nicotinamide riboside (NR).

Occupational therapy's role in promoting the "Learn the Signs. Act Early." developmental monitoring program to public health employees.

Background: Occupational therapists can play a key role in early identification of delay at the population health level by providing education to public health employees on how to implement developmental monitoring with caregivers of children birth to age 5.

Methods: A pretest posttest design was utilized to assess the online education and training that was provided to Department of Public Health employees ( = 339), including Head Start, Special Supplemental Nutrition Program for Women, Infants and Children, Home Visiting, and Early Intervention.

Results: Analysis of pretest-posttest survey data showed significant results for all 12 key learning outcomes.

Free-Living Sleep, Food Intake, and Physical Activity in Night and Morning Shift Workers.

Shift work is associated with risk for adverse health outcomes including cardiovascular disease, type 2 diabetes, cancer, and obesity. Short sleep duration combined with disruptions to the circadian system may alter factors involved with the behavioral regulation of energy intake and expenditure. We aimed to determine how shift work affects sleep, food intake, and physical activity.

Objective Food Intake in Night and Day Shift Workers: A Laboratory Study.

Night shift work is associated with risk of overweight and obesity. In night shift workers, short sleep duration combined with circadian misalignment may contribute to altered food intake regulation, favoring positive energy balance and weight gain. Prior work investigating food intake in shift workers has suffered methodologically due to reliance on subjective self-report for dietary assessment.

Interfacing microchip isoelectric focusing with on-chip electrospray ionization mass spectrometry.

In this work, we demonstrate the interfacing of microchip capillary isoelectric focusing (cIEF) with online mass spectrometric (MS) detection via a fully integrated, on-chip sheath flow electrospray ionization (ESI) emitter. Thanks to the pH-dependent surface charge of the SU-8 polymer cIEF can be successfully run in native SU-8 microchannels without need for surface pretreatment prior to analysis. On the other hand, the inherent electroosmotic flow (EOF) taking place in SU-8 microchannels at high pH can be exploited to electrokinetic mobilization of the focused pH gradient toward the MS and no external pumps are required.