Publications by authors named "S Latour"
Primary effusion lymphoma (PEL) is a rare B-cell non-Hodgkin lymphoma associated with Kaposi Sarcoma-associated herpesvirus (KSHV/HHV8) infection. Lymphoma cells are coinfected with Epstein-Barr virus (EBV) in 60-80% of cases. Tools allowing a reliable PEL diagnosis are lacking.
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- Identifying cells infected by Epstein-Barr virus (EBV) is crucial for understanding the disease's development, creating treatment plans, and predicting patient outcomes.
- The study utilized the PrimeFlow™ RNA Assay Kit to detect EBV-encoded small RNAs (EBERs) in various patient groups, including those with chronic active EBV disease and other EBV-related disorders.
- Findings revealed that patients with chronic active EBV disease showed widespread infection in T and NK cells, while other disorders demonstrated a mix of infected cell types, indicating that EBV may affect multiple cell types beyond just B cells.
Article Synopsis
- * Inherited mutations affecting T cell immunity, particularly biallelic variants in IL27RA, can result in severe primary EBV infections, with one allele more common in the Finnish population linked to increased risk of severe IM.
- * IL-27 and its receptor IL-27RA play a significant role in T cell response to EBV; deficiencies in IL-27RA lead to impaired T cell growth against the virus, yet these same deficiencies could explain why some patients recover well despite severe initial infections.