Publications by authors named "S Lata Muralidhar"

Objectives: In 2016, the Department of Veterans Affairs (VA) and the Department of Energy (DOE) established an Interagency Agreement (IAA), the Million Veteran Program-Computational Health Analytics for Medical Precision to Improve Outcomes Now (MVP-CHAMPION) research collaboration.

Materials And Methods: Oversight fell under the VA Office of Research Development (VA ORD) and DOE headquarters. An Executive Committee and 2 senior scientific liaisons work with VA and DOE leadership to optimize efforts in the service of shared scientific goals.

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  • * Out of 876 providers, only 10% were aware of their patients' PGx test status, with 64% not having ordered any PGx tests in the past year.
  • * Most providers (55%) believed PGx testing could be valuable for pain medication prescriptions, and 51% indicated a need for local experts to assist with PGx testing, highlighting areas for improvement in the Veterans Health Administration's approach to pain management.
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Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous lung cancer GWAS have identified numerous loci, but separating the genetic risks of lung cancer and smoking behavioral susceptibility remains challenging. Here, we perform multi-ancestry GWAS meta-analyses of lung cancer using the Million Veteran Program cohort (approximately 95% male cases) and a previous study of European-ancestry individuals, jointly comprising 42,102 cases and 181,270 controls, followed by replication in an independent cohort of 19,404 cases and 17,378 controls.

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  • The study focused on identifying self-reported military and occupational exposures among Veterans, such as Agent Orange and chemical warfare agents, through the Million Veteran Program, which gathers health data from over a million US Veterans.
  • Over 500,000 participants detailed their military experiences, revealing significant differences in reported exposures based on factors like service era, combat deployment, and occupation, with Vietnam-era Veterans primarily reporting Agent Orange exposure.
  • The findings indicate that exposure patterns varied notably by demographics, with combat-related occupations showing higher exposure reports compared to healthcare roles, aligning with previous research on US military Veterans.
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Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electronic health records of 200,000 individuals of African ancestry in the Million Veteran and All of Us Research Programs, and, coupled with genotype-level data from four case-control studies, realized a combined sample size of 13,012 affected and 54,266 unaffected persons. Three genome-wide significant signals - near , , and - are the first to be independently identified in populations of predominantly African ancestry.

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