Publications by authors named "S Lartigue"
Background: This study aims to understand the demographic representation of patients in Traumatic Brain Injury (TBI) clinical trials by evaluating the proportions of patients from various demographic categories amongst completed TBI clinical trials in the United States.
Methods: ClinicalTrials.gov was queried for active TBI clinical trials.
Introduction: Although stress has been associated with eating behaviors, such as overeating and eating less healthy foods, the relationships between specific types of parent stressors and fast-food consumption in parents and young children have not been well studied. We hypothesized that parent perceived stress, parenting stress, and household chaos would be positively associated with fast-food consumption for parents and their young children.
Methods: Parents of 2-5 year olds and with Body Mass Index >27 kg/m (N = 234, parent mean age: 34.
Improvements in the biological control of agricultural pests require improvements in the phenotyping methods used by practitioners to select efficient biological control agent (BCA) populations in industrial rearing or field conditions. Consistent inter-individual variations in behaviour (i.e.
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- Preeclampsia (PE) is a serious pregnancy condition that occurs due to improper trophoblast cell invasion affecting blood circulation between the mother and fetus.
- CK2, an enzyme involved in cellular processes, was found to be more active during early pregnancy and its inhibition negatively impacted trophoblast cell functions essential for healthy development.
- The study observed that CK2 activity increases in placentas from PE patients and in PE mouse models, suggesting its role in supporting feto-maternal circulation, potentially indicating a compensatory response to the challenges in PE.
Although the number of proteins effectively targeted for posttranslational degradation by PROTAC has grown steadily, the number of E3 ligases successfully exploited to accomplish this has been limited to the few for which small-molecule ligands have been discovered. Although the E3 ligase MDM2 is bound by the nutlin class of small-molecule ligands, there are few nutlin-based PROTAC. Because a nutlin-based PROTAC should both knockdown its target protein and upregulate the tumor suppressor p53, we examined the ability of such a PROTAC to decrease cancer cell viability.
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