Publications by authors named "S Langdon"
Article Synopsis
- Intertrochanteric hip fractures are becoming more common due to an aging population, and cephalomedullary nailing is increasingly used as a treatment option.
- A unique case is reported where a patient developed heterotopic ossification in the proximal femur after this procedure, leading to a serious complication: a femoral artery pseudoaneurysm.
- The situation required a collaborative surgical approach from both vascular and orthopedic teams, marking this case as one of the first documented instances in the literature.
Article Synopsis
- * The study found that elevated levels of the DNA repair protein FANCD2 in platinum-resistant HGSOC cell lines contribute to reduced sensitivity to the chemotherapy drug carboplatin; reducing FANCD2 levels increased sensitivity.
- * The research suggests that the protein mTOR may regulate FANCD2 expression, linking it to chemoresistance, and indicates that varying FANCD2 levels in tumors do not significantly relate to clinical traits but might affect tumor migration.
Purpose: Despite a rise in clinical use of radiopharmaceutical therapies, the biological effects of radionuclides and their relationship with absorbed radiation dose are poorly understood. Here, we set out to define this relationship for Auger electron emitters [Tc]TcO and [I]I and βparticle emitter [Re]ReO. Studies were carried out using genetically modified cells that permitted direct radionuclide comparisons.
View Article and Find Full Text PDFBackground: DNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenance pathways, was investigated to characterise its impact in HGSOC.
Methods: RFWD3 expression and association with clinical features was assessed using analysis in the TCGA HGSOC dataset, and in a further cohort of HGSOC tumours stained for RFWD3 using immunohistochemistry.
Article Synopsis
- The Radiation Reveal project brought together ten young adults aged 17-25 who had experience with radiotherapy and researchers to talk about their experiences over three online workshops.
- * The project aimed to help these young adults share what they wish they had known about radiotherapy, and they ended up building friendships, support groups, and creating helpful tips for medical professionals.
- * A key part of the project’s success was having someone passionate in charge and making sure to get feedback from charities and young adults throughout the process.