StAC-DA: Structure aware cross-modality domain adaptation framework with image and feature-level adaptation for medical image segmentation.

Objective: Convolutional neural networks (CNNs) have achieved state-of-the-art results in various medical image segmentation tasks. However, CNNs often assume that the source and target dataset follow the same probability distribution and when this assumption is not satisfied their performance degrades significantly. This poses a limitation in medical image analysis, where including information from different imaging modalities can bring large clinical benefits.

Automated Uniform Spheroid Generation Platform for High Throughput Drug Screening Process.

Three-dimensional (3D) spheroid models are crucial for cancer research, offering more accurate insights into tumour biology and drug responses than traditional 2D cell cultures. However, inconsistent and low-throughput spheroid production has hindered their application in drug screening. Here, we present an automated high-throughput platform for a spheroid selection, fabrication, and sorting system (SFSS) to produce uniform gelatine-encapsulated spheroids (GESs) with high efficiency.

DistilIQA: Distilling Vision Transformers for no-reference perceptual CT image quality assessment.

No-reference image quality assessment (IQA) is a critical step in medical image analysis, with the objective of predicting perceptual image quality without the need for a pristine reference image. The application of no-reference IQA to CT scans is valuable in providing an automated and objective approach to assessing scan quality, optimizing radiation dose, and improving overall healthcare efficiency. In this paper, we introduce DistilIQA, a novel distilled Vision Transformer network designed for no-reference CT image quality assessment.

Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling.

Purpose: Our previous screening studies identified Oroxylin A (OXA) as a strong inhibitor on the carboxyolesterase mediated hydrolysis of irinotecan to SN-38. The current study employed a whole-body physiologically based pharmacokinetic (PBPK) modeling approach to investigate the underlying mechanisms of the carboxylesterase-mediated pharmacokinetics interactions between irinotecan and OXA in rats.

Methods: Firstly, rats received irinotecan intravenous treatment at 35 μmol/kg without or with oral OXA pretreatment (2800 μmol/kg) daily for 5 days.

Should nails be locked dynamically or statically in atypical femoral fractures? - A radiological analysis of time to union and reoperations in 236 displaced fractures with 4 years average follow-up.

Introduction: Atypical femoral fractures (AFFs) are associated with delayed union and higher reoperation rates. Axial dynamization of intramedullary nails is hypothesized to reduce time-to-union (TTU) and fixation failure as compared to static locking.

Methods: Consecutive acutely displaced AFFs fixed with long intramedullary nails across five centres between 2006 and 2021 with a minimum postoperative follow-up of three months were retrospectively reviewed.