Publications by authors named "S Lagoo"
Article Synopsis
- The study investigates the impact of age on outcomes for elderly patients undergoing lower extremity bypass surgery, focusing on modifiable factors that could improve their care quality and financial sustainability under bundled payment models initiated by CMS.
- Analysis of data from over 5,300 patients revealed that older age correlates with higher rates of cardiopulmonary diseases and critical limb ischemia, while younger patients had higher rates of diabetes and tobacco use.
- Key findings include that while older patients had longer hospital stays and more transfusion needs, the rate of amputations within 30 days post-surgery was not significantly different across age groups.
Evidence is mixed for an association between serum insulin-like growth factor-I (IGF-I) levels and postoperative delirium (POD). The current study assessed preoperative serum IGF-I levels as a predictor of incident delirium in non-demented elderly elective knee arthroplasty patients. Preoperative serum levels of total IGF-I were measured using a commercially available Human IGF-I ELISA kit.
View Article and Find Full Text PDFDespite the growth of the elderly population, most surgical training programs lack formalized geriatric education. The authors' aim was to implement a formalized geriatric surgery curriculum at an academic medical center. Surgery residents were surveyed on attitudes toward the care of elderly patients and the importance of various geriatric topics to daily practice.
View Article and Find Full Text PDFObjectives: To compare outcomes and the use of multimodality therapy in young and elderly people with pancreatic cancer undergoing surgical resection.
Design: Retrospective, single-institution study.
Setting: National Cancer Institute/National Comprehensive Cancer Network cancer center.
The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs). The aim of this study was to evaluate the effect of age on the modulation of TLRs and IRAK-1 and IRAK-M in peripheral blood mononuclear cells (PBMCs) exposed in vitro to endotoxin under conditions that could induce endotoxin tolerance. Peripheral blood mononuclear cells obtained from young (4- to 6-month-old) and aged (24- to 26-month-old) Brown Norway rats were treated with high-dose LPS, with or without priming with low-dose LPS.
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