Publications by authors named "S Lagana"
Article Synopsis
- * A study demonstrates that metallothionein (MTH) immunohistochemistry (IHC) is a highly effective diagnostic method for WD, showing high sensitivity (91.20%) and perfect specificity (100%) in a cohort of 91 patients compared to control samples.
- * MTH IHC could serve as a cost-effective and reliable screening tool for diagnosing WD in patients of different ages and disease stages, enhancing patient evaluation and management.
Article Synopsis
- The study investigates the relationship between systemic bile acids and the progression of Barrett's esophagus (BE), particularly their role in advancing stages that may lead to esophageal adenocarcinoma (EAC).
- It involved profiling serum bile acids in 141 subjects (both with and without BE) and examined how various factors, like diet and age, influenced bile acid levels, finding significant differences between non-BE and BE stages.
- Results indicate that higher levels of specific bile acids, especially cholic acid, are linked to advanced BE conditions and gene expression changes, suggesting that they may serve as potential biomarkers or targets for future therapeutic strategies.
Article Synopsis
- High-risk features in colorectal adenomatous polyps are identified by their size (greater than 1 cm) and advanced histology, which includes high-grade dysplasia (HGD) and villous architecture.
- A study involving nine academic institutions analyzed data on 2,700 polyps from 1,886 patients to compare the rates of advanced histology and found significant variability among institutions, with rates for advanced histology ranging from 1.7% to 9.3%.
- The factor most closely linked to advanced histology was polyp size greater than 1 cm, with a strong odds ratio of 31.82, indicating that differences in polyp sizes across institutions could help explain variation in diagnostic rates,
Article Synopsis
- The study investigates the occurrence of pagetoid spread in esophageal squamous cell carcinomas (ESCC), a condition previously mainly associated with esophageal adenocarcinoma (EAC), through seven identified cases from multiple pathology archives.
- Researchers compared the clinical and morphological details of pagetoid spread in ESCC cases to those in EAC to highlight differences and similarities, noting that pagetoid spread in ESCC is underreported.
- The findings reveal that most patients with ESCC exhibiting pagetoid spread were older adults, predominantly female, and that distinct immunohistochemical markers (like positive p40 and p63) may aid in identifying these cases.