Publications by authors named "S Lacombe"

Article Synopsis
  • This work investigates a new cancer treatment strategy using porous metal-organic frameworks (nanoMOFs) combined with the anti-cancer drug Gemcitabine monophosphate (GemMP) and particle therapy, which improves precision in targeting tumors compared to traditional radiotherapy.
  • The study addresses key challenges in cancer therapy, particularly the impact of hypoxia and the microenvironment around tumors, showing that GemMP-loaded nanoMOFs enhance the effectiveness of particle therapy in both oxygen-rich and oxygen-poor conditions while allowing for lower radiation doses.
  • The research concludes that nanoMOFs significantly improve drug delivery to cancer cells, demonstrating potential for developing "all-in-one" nanodrugs that optimize treatment and increase the cytotoxic effects on hypoxic tumors.
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Background: Since the 2000's, plants have been used as bioreactors for the transient production of molecules of interest such as vaccines. To improve protein yield, "amplicon" vectors based on plant viruses are used. These viral constructs, engineered to carry the gene of interest replicate strongly once introduced into the plant cell, allowing significant accumulation of the protein.

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In the Arctic tundra, predators face recurrent periods of food scarcity and often turn to ungulate carcasses as an alternative food source. As important and localized resource patches, carrion promotes co-occurrence of different individuals, and its use by predators is likely to be affected by interspecific competition. We studied how interspecific competition and resource availability impact winter use of carrion by Arctic and red foxes in low Arctic Fennoscandia.

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Background: The fruity aromatic bouquet of coffee has attracted recent interest to differentiate high value market produce as specialty coffee. Although the volatile compounds present in green and roasted coffee beans have been extensively described, no study has yet linked varietal molecular differences to the greater abundance of specific substances and support the aroma specificity of specialty coffees.

Results: This study compared four Arabica genotypes including one, Geisha Especial, suggested to generate specialty coffee.

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Article Synopsis
  • Platinum nanoparticles (Pt NPs) show great promise in nanomedicine due to their high electron density and surface area, with intravenous injection being the preferred delivery method.
  • Research using synchrotron radiation circular dichroism (SRCD) explored how these nanoparticles interact with human serum albumin (HSA), a key blood component, showing no strong complexation except for some increased thermal stability at a specific nanoparticle-to-protein ratio.
  • The study suggests a quick method to assess the potential toxicity of Pt NPs for clinical use, particularly for intravenous applications.
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