Esketamine alleviates LPS-induced depression-like behavior by activating Nrf2-mediated anti-inflammatory response in adolescent mice.

Background: The mechanisms underlying esketamine's therapeutic effects remain elusive. The study aimed to explore the impact of single esketamine treatment on LPS-induced adolescent depressive-like behaviors and the role of Nrf2 regulated neuroinflammatory response in esketamine-produced rapid antidepressant efficacy.

Methods: Adolescent male C57BL/6J mice were randomly assigned to three groups: control, LPS, and LPS + esketamine (15 mg/kg, i.

Study on dynamic compression characteristics of coal containing gas under different strain rates.

To investigate the dynamic compression properties and crushing features of gas-containing coal under complex geological environments, a dynamic and static combined loading test system was independently developed for conducting triaxial dynamic compression tests. The dynamic stress-strain curves under different strain rates were analyzed to study the effects of strain rate and gas pressure on the dynamic mechanical characteristics. Crushed coal samples were sieved and analyzed using a standard sieve and fractal theory.

"Raman plus X" dual-modal spectroscopy technology for food analysis: A review.

Raman spectroscopy, a nondestructive optical technique that provides detailed chemical information, has attracted growing interest in the food industry. Complementary spectroscopic methods, such as near-infrared (NIR) spectroscopy, nuclear magnetic resonance (NMR), terahertz (THz) spectroscopy, laser-induced breakdown spectroscopy (LIBS), and fluorescence spectroscopy (Flu), enhance Raman spectroscopy's capabilities in various applications. The integration of Raman with these techniques, termed "Raman plus X," has shown significant potential in agri-food analysis.

[Therapeutic effects of glucocorticoids in patients with hematologic diseases with neutropenia and severe pneumonia classified by the PSI scores].

This study aimed to investigate the clinical value of glucocorticoids in patients with neutropenic severe pneumonia at moderate to high risk according to the Pneumonia Severity Index (PSI) in patients with hematologic diseases. Clinical data were collected from 534 patients at the Fujian Medical University Union Hospital from October 2016 to December 2018. We evaluated the changes in inflammatory cytokines, treatment failure, in-hospital mortality, and other outcomes, adjusting for potential confounders through propensity score matching.

[Maribavir treatment for refractory and drug-intolerant cytomegalovirus viremia and disease after allogeneic hematopoietic stem cell transplantation: a clinical analysis of 25 cases].

To investigate the safety and efficacy of maribavir for the treatment of CMV viremia and CMV disease refractory or intolerant to conventional antiviral drugs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) . This study retrospectively analyzed the clinical characteristics and outcomes of CMV viremia and CMV disease refractory or intolerant to conventional antiviral drugs after allo-HSCT treated with maribavir at Hebei Yanda Lu Daopei Hospital from April 2024 to September 2024. A total of 25 patients received maribavir, including 21 haploidentical transplants, two sibling HLA-matched transplants, and 2 HLA-matched unrelated transplants.