Publications by authors named "S L Weibel"
Informing pandemic management in Germany with trustworthy living evidence syntheses and guideline development: lessons learned from the COVID-19 evidence ecosystem.
J Clin Epidemiol
September 2024
Objectives: We present the 'COVID-19 evidence ecosystem' (CEOsys) as a German network to inform pandemic management and to support clinical and public health decision-making. We discuss challenges faced when organizing the ecosystem and derive lessons learned for similar networks acting during pandemics or health-related crises.
Study Design And Setting: Bringing together 18 university hospitals and additional institutions, CEOsys key activities included research prioritization, conducting living systematic reviews (LSRs), supporting evidence-based (living) guidelines, knowledge translation (KT), detecting research gaps, and deriving recommendations, backed by technical infrastructure and capacity building.
Article Synopsis
- - The study evaluated the effectiveness of antigen rapid diagnostic tests (Ag-RDT) and RT-qPCR in detecting infectious SARS-CoV-2 by comparing them with virus isolation as a reference.
- - Out of 20 studies reviewed, both tests showed varying levels of sensitivity and specificity, with Ag-RDT showing 93% sensitivity and 87% specificity, while RT-qPCR had 98% sensitivity but only 45% specificity.
- - The findings highlight that while Ag-RDT can identify most infectious samples, RT-qPCR's high sensitivity doesn't necessarily indicate true infectivity due to its low specificity, and both tests have limitations that should be considered when interpreting results.
Background: Historically, the majority of patients admitted to inpatient exercise-based cardiac rehabilitation (EBCR) have undergone open heart surgery (OHS). However, with advances in minimally invasive cardiac surgery (MICS), these patient groups are also increasingly referred for inpatient EBCR. Herein, we aimed to compare the progress of these groups during rehabilitation.
View Article and Find Full Text PDFBackground: Thromboembolic events are common complications of COVID-19. Clinical study results on safety and efficacy of anticoagulation in COVID-19 are controversial.
Material And Methods: This report is the second update of our systematic review with meta-analysis on randomized controlled trials (RCTs) comparing standard thromboprophylaxis, intermediate or therapeutic dose anticoagulation or no anticoagulation in COVID-19 in- and outpatients.