Publications by authors named "S L Wall"
High-dose methotrexate (MTX) results in high rates of acute kidney injury (AKI), neutropenia, and hepatotoxicity. Glucarpidase is a recombinant enzyme that cleaves MTX, but clinical data supporting its use are scarce. We examined the association between glucarpidase administration and outcomes in adults with MTX-AKI from 28 cancer centers across the U.
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- This study focused on understanding how common diagnostic uncertainty is when critically ill children are admitted to Pediatric Intensive Care Units (PICUs) and what factors contribute to it.
- Researchers reviewed medical records from 882 pediatric patients across four hospitals to assess the presence of diagnostic uncertainty at admission and how it changed by the time of discharge.
- Key findings indicated that 25.9% of patients showed diagnostic uncertainty upon PICU admission, with significant factors being the time of admission, illness severity, atypical symptoms, and discrepancies in diagnoses between different healthcare providers.
Article Synopsis
- Adverse events in healthcare are prevalent and can negatively affect both patients and the healthcare system, particularly highlighted by a lack of South African data.
- The study analyzed ten years of electronic medical records from December 2012 to January 2023, documenting 14,537 adverse events from over 52,000 admissions, which represents an overall rate of 22%.
- The majority of adverse events were related to clinical care, with significant occurrences linked to indwelling devices and iatrogenic injuries, emphasizing the need for a comprehensive approach to reduce these incidents.