Publications by authors named "S L Vig"
While surgical resection is a mainstay of cancer treatment, many tumors are unresectable due to stage, location, or comorbidities. Ablative therapies, which cause local destruction of tumors, are effective alternatives to surgical excision in several settings. Ethanol ablation is one such ablative treatment modality in which ethanol is directly injected into tumor nodules.
View Article and Find Full Text PDFScreening of photosensitizers-ATP binding cassette (ABC) transporter interactions .
Cancer Drug Resist
September 2024
Article Synopsis
- This study explores how ATP-binding cassette (ABC) transporters reduce the effectiveness of cancer treatments by transporting seven clinically used photosensitizers out of cancer cells.* -
- The research involved human breast cancer cell lines to assess how specific transport proteins (P-gp, ABCG2, MRP1) affect the accumulation of these photosensitizers, with some inhibitors showing effectiveness in blocking transport.* -
- Key findings indicate that certain photosensitizers can be impacted by these transporters, leading to reduced efficacy in photodynamic therapy, while others, like temoporfin and talaporfin sodium, do not seem to be transported by ABCG2.*
Palliative Care Aspects of Acute Intermittent Porphyria - A Case Report.
Indian J Palliat Care
August 2024
Acute intermitttent porphyria belongs to a rare group of diseases hallmarked by deficient biosynthesis of heme. It carries a significant symptom burden, both physical and emotional,and therefore palliative care has emerged as an essential tool in the armamentarium of porphyria management . It takes care of the patient as a whole and caters to all aspects that the disease process demands.
View Article and Find Full Text PDFBone substitutes are widely employed for applications in orthopedic surgery for the replacement of injured bone. Among the diverse methods that are used to design 3D bioceramic matrices, Freeze Foaming has gained attention, since it provides the ability to tune the shape of the created structures. One of the major problems related to these constructs is the lack of porosity at the outwards sides (holder) of the scaffold, thus reducing the cellular affinity and creating a rejection of the implant.
View Article and Find Full Text PDFAims: The aims of this study were to describe the demographic, socioeconomic, and educational factors associated with core surgical trainees (CSTs) who apply to and receive offers for higher surgical training (ST3) posts in Trauma & Orthopaedics (T&O).
Methods: Data collected by the UK Medical Education Database (UKMED) between 1 January 2014 and 31 December 2019 were used in this retrospective longitudinal cohort study comprising 1,960 CSTs eligible for ST3. The primary outcome measures were whether CSTs applied for a T&O ST3 post and if they were subsequently offered a post.