Publications by authors named "S L Stocker"
Article Synopsis
- The study focuses on the patterns of medication adherence among gout patients using allopurinol and how these patterns affect serum urate levels and clinical outcomes.
- It finds that while occasional missed doses may not drastically impact urate control, consistently taking breaks of more than three days significantly lowers the likelihood of achieving adequate urate levels.
- The research emphasizes the importance of understanding individual medication-taking habits to improve treatment outcomes for gout patients.
Introduction: Pyrazinamide, one of the first-line antituberculosis drugs, displays variability in drug exposure that is associated with treatment response. A simple, low-cost assay may be helpful to optimize treatment. This study aimed to develop and validate a point-of-care assay to quantify the concentration of pyrazinamide in saliva.
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- * The study analyzed data from 258 gout patients and found that increased oxypurinol exposure is necessary for effective urate reduction in those with decreased kidney function or on diuretics, despite lower overall dose requirements at severe kidney impairment.
- * Ultimately, the research concluded that patients with significant kidney impairment need lower allopurinol doses, but these doses do not directly correlate with kidney function, and diuretics do not affect required doses.
Aims: The aim of this study was to examine contemporary trends in the use of, time to, and type of first add-on anti-hyperglycaemic therapy to metformin in Australia.
Methods: We used the dispensing records of a 10% random sample of Pharmaceutical Benefits Scheme (PBS) eligible people. We included people aged 40 years and older initiating metformin from 1 January 2018 to 31 December 2020.