Publications by authors named "S L Stang"
Background: The global maternal mortality rate has increased annually. This study aimed to examine the role of emotional support and the social support theraphy on the experience of emergency caesarean deliveries.
Methods: The narrative study was conducted using scientific journal database sources from PubMed, Proquest, Ebsco, Science Direct, and Google Scholar from 2016 to 2023.
Article Synopsis
- - The study highlights the creation of patient-derived colorectal cancer organoids (PDOs) and their co-culturing with cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) to better mimic the tumor environment and understand treatment responses.
- - Researchers utilized advanced techniques such as single-cell transcriptomics and flow cytometry to analyze the interactions between these cells and how they respond to chemotherapy and oncolytic viral treatments.
- - Results showed that combining CAFs with tumor cells and monocytes led to a more immunosuppressive macrophage phenotype, but that chemotherapy could trigger a pro-inflammatory response and enhance macrophage activity in fighting CRC cells.
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1, IL-1-high-signaling subtype of fibroblasts, using multiple colorectal cancer (CRC) patient single cell sequencing datasets. This subtype of fibroblasts is linked to T cell and macrophage suppression and leads to increased cancer cell growth in 3D co-culture assays.
View Article and Find Full Text PDFColorectal cancer (CRC) is the second deadliest cancer in the world. Besides APC and p53 alterations, the PI3K/AKT/MTOR and MAPK pathway are most commonly mutated in CRC. So far, no treatment options targeting these pathways are available in routine clinics for CRC patients.
View Article and Find Full Text PDFFibroblasts are the most abundant stromal constituents of the tumour microenvironment in primary as well as metastatic colorectal cancer (CRC). Their supportive effect on tumour cells is well established. There is growing evidence that stromal fibroblasts also modulate the immune microenvironment in tumours.
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