Publications by authors named "S L Simms"

Family Based Mental Health Services (FBMHS) with an embedded clinical model, Ecosystemic Structural Family Therapy, is an intervention designed for youth with a serious emotional disturbance (SED) who are at risk of out-of-home placement. The current evaluation examines the association between receipt of FBMHS and rates of out-of-home and community-based care during and after an episode of FBMHS. We identified 25,016 Medicaid-enrolled youth ages 3 to 17 years with receipt of a new FBMHS episode from 1/1/2015 to 6/30/2021.

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Transmembrane protein 135 (TMEM135) is a 52 kDa protein with five predicted transmembrane domains that is highly conserved across species. Previous studies have shown that TMEM135 is involved in mitochondrial dynamics, thermogenesis, and lipid metabolism in multiple tissues; however, its role in the inner ear or the auditory system is unknown. We investigated the function of TMEM135 in hearing using wild-type (WT) and ( ) mutant mice on a CBA/CaJ background, a normal-hearing mouse strain.

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Article Synopsis
  • The study examines the role of estrogen receptor 1 (ESR1) in auditory and balance functions using wild-type (WT) and knockout (KO) mice, focusing on the effects of estrogen on the nervous system.
  • While KO female mice had lower body weights compared to KO males, no significant differences were found in measures of auditory function or balance performance between WT and KO mice.
  • The results suggest that estrogen receptor 1 deficiency does not impair auditory or balance functions in normal-hearing mice, indicating potential compensation by estrogen receptor 2 or other estrogen receptors.
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It is important to consider reciprocal associations between maternal and offspring mental health problems during early childhood. Existing interventions often focus narrowly on either adult or child mental health, missing the opportunity for holistic care. We describe the rationale and development of a pilot randomized clinical trial that explores their integration, combining an evidence-based parenting intervention with depression treatment to improve both maternal and child outcomes.

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