Publications by authors named "S L Sergio"
β-Catenin/c-Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations.
Adv Biol (Weinh)
January 2025
Ammonia a by-product of nitrogen containing molecules is detoxified by liver into non-toxic urea and glutamine. Impaired ammonia detoxification leads to hyperammonemia. Ammonia has a dual role on autophagy, it acts as inducer at low concentrations and as inhibitor at high concentrations.
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- A study was conducted to see if adding platelet reactivity (PR) evaluation to the existing ACEF score could enhance the diagnostic accuracy for patients with stable coronary artery disease (CAD) treated with percutaneous coronary intervention.
- The findings showed that the new PR-ACEF score significantly outperformed the original ACEF score in predicting outcomes such as death and myocardial infarction (MI) as well as major adverse cardiovascular events (MACE).
- The PR-ACEF score also demonstrated strong long-term predictive ability, with high values indicating a greater risk of death/MI and MACE over a 5-year period.
Background And Aims: Conflicting data are available regarding the association between periprocedural myocardial infarction (PMI) and mortality following percutaneous coronary intervention. The purpose of this study was to evaluate the incidence and prognostic implication of PMI according to the Universal Definition of Myocardial Infarction (UDMI), the Academic Research Consortium (ARC)-2 definition, and the Society for Cardiovascular Angiography and Interventions (SCAI) definition.
Methods: Studies reporting adjusted effect estimates were systematically searched.
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, primarily associated with dopaminergic neuron depletion in the Substantia Nigra. Current treatment focuses on compensating for dopamine (DA) deficiency, but the blood-brain barrier (BBB) poses challenges for effective drug delivery. Using differentiated SH-SY5Y cells, we investigated the co-administration of DA and the antioxidant Grape Seed Extract (GSE) to study the cytobiocompability, the cytoprotection against the neurotoxin Rotenone, and their antioxidant effects.
View Article and Find Full Text PDFThe uc.291 transcript controls keratinocytes differentiation by physical interaction with ACTL6A and subsequent induction of transcription of the genes belonging to the epidermal differentiation complex (EDC). Uc.
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