Publications by authors named "S L Samson"
With aging, the risk of fractures and compromised healing increases. Angiogenesis plays a significant role in bone healing and is impaired with aging. We have previously shown the impact of megakaryocytes (MKs) in regulating bone healing.
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- The study focuses on the significance of influenza vaccination in patients with acute myocardial infarction (AMI) and evaluates methods to enhance vaccine uptake among this high-risk group.
- The research consists of three nationwide randomized clinical trials conducted in Denmark that tested the effectiveness of electronically delivered behavioral nudges against usual care in increasing vaccination rates among AMI patients.
- The primary outcome measured was the rate of influenza vaccinations received, with findings suggesting that these behavioral nudges could potentially improve vaccination uptake in the targeted population.
Epidural Interlay Graft for Pituitary Surgery: A 4-Year Institutional Experience.
J Neurol Surg B Skull Base
October 2024
Article Synopsis
- - The study investigates the effectiveness of a minimalistic sellar repair technique using an epidural interlay graft to prevent cerebrospinal fluid (CSF) leaks after endoscopic transsphenoidal pituitary surgery.
- - Out of 334 cases reviewed, intraoperative CSF leaks occurred in 34.7%, but only one postoperative leak was noted (0.3%), highlighting the technique's success and leading to a reduction in more complex repair strategies over time.
- - The study reports a 65% remission rate for functional macroadenomas, with the interlay graft being a reliable and effective solution, resulting in no postoperative CSF leaks in over 300 surgeries at the institution.
Pre-cancerous lung lesions are commonly initiated by activating mutations in the RAS pathway, but do not transition to lung adenocarcinomas (LUAD) without additional oncogenic signals. Here, we show that expression of the extracellular matrix protein Tenascin-C (TNC) is increased in and promotes the earliest stages of LUAD development in oncogenic KRAS-driven lung cancer mouse models and in human LUAD. TNC is initially expressed by fibroblasts and its expression extends to tumor cells as the tumor becomes invasive.
View Article and Find Full Text PDFTime of day for vaccination, outcomes, and relative effectiveness of high-dose vs. standard-dose quadrivalent influenza vaccine: A post hoc analysis of the DANFLU-1 randomized clinical trial.
J Infect
November 2024
Article Synopsis
- - The study aimed to examine how the timing of influenza vaccinations (morning vs. later in the day) affects the immune response and overall health outcomes, particularly in a large trial comparing high-dose and standard-dose influenza vaccines.
- - Researchers analyzed data from 12,477 participants and found that earlier vaccinations were linked to fewer hospitalizations for respiratory issues, regardless of the vaccine dosage, with statistically significant results.
- - Although both high-dose and standard-dose vaccines showed similar effectiveness regardless of vaccination timing, the findings suggest that getting vaccinated earlier in the day could still be beneficial, warranting further investigation.