Publications by authors named "S L Riddle"
Objective: To estimate inter-center variation (ICV) in hospital length of stay (LOS) and oral feeding at discharge among infants with gastroschisis.
Study Design: The Children's Hospitals Neonatal Consortium's (CHNC) database was used to identify hospitalized survivors with gastroschisis. Two outcomes were evaluated: LOS and discharge without tube feedings.
Article Synopsis
- Pulmonary hypertension (PH) severely affects exercise ability and quality of life by impacting various organ systems like the right ventricle, lungs, and muscles.
- Recent studies suggest that issues with metabolism and mitochondria are key factors in the reduced exercise tolerance seen in PH patients.
- This research found that using the SIRT3 activator Honokiol with NAD significantly improved exercise performance in a PH rat model, mainly by enhancing mitochondrial function in skeletal muscles and reducing muscle wasting, highlighting a potential therapeutic strategy for PH patients.
Article Synopsis
- The Children's Hospitals Neonatal Consortium (CHNC), founded in 2010, aims to enhance care for seriously ill infants in level IV NICUs across North America through data collection, benchmarking, and quality improvement.
- CHNC has made strides in the treatment of various surgical conditions like congenital diaphragmatic hernia and gastroschisis by promoting collaboration among institutions and creating focus groups for specific diagnoses.
- Additionally, the consortium emphasizes the importance of addressing post-birth hospitalization needs and explores the role of telemedicine in improving care for these infants.
Objective: To examine neonatal outcomes of infants with gastroschisis born <32 weeks' gestation compared to matched infants without gastroschisis.
Study Design: Retrospective matched-cohort analysis of infants with gastroschisis born <32 weeks' gestation at Children's Hospitals Neonatal Consortium (CHNC) NICUs from 2010 to 2022 compared to gestational age-matched controls.
Results: The study included 119 infants with gastroschisis and 357 matched infants; 60% of infants born 29-32 weeks, 23% born 26-28 weeks, and 16% born < 25 weeks.