Host Index and Gallbladder Cancer: An Emerging Prognostic Biomarker.

Background And Objectives: There is emerging evidence that host related variables predict outcomes in various cancers. The Host index (H-index) incorporates various host-related, blood-derived biomarkers (immunological and nutritional parameters) as a single mathematical formula. The aim of this study was to evaluate outcomes using the H-index as a prognostic marker in gallbladder cancer (GBC) patients undergoing curative resection.

Primary Liver Rhabdomyosarcoma with Burnt-out Paravertebral Disease.

Less than 20 cases of primary hepatic rhabdomyosarcoma have been reported in literature. The authors present this occurrence in a neonate with paravertebral and peritoneal disease. Histopathology was the solution to authors' diagnostic dilemma.

Predicting the tumor microenvironment composition and immunotherapy response in non-small cell lung cancer from digital histopathology images.

Immune checkpoint inhibitors (ICI) have become integral to treatment of non-small cell lung cancer (NSCLC). However, reliable biomarkers predictive of immunotherapy efficacy are limited. Here, we introduce HistoTME, a novel weakly supervised deep learning approach to infer the tumor microenvironment (TME) composition directly from histopathology images of NSCLC patients.