Publications by authors named "S L Mason"
Background: The number of U.S. deaths due to child maltreatment (abuse and neglect) has been increasing over several years.
View Article and Find Full Text PDFDelandistrogene moxeparvovec is an rAAVrh74 vector-based gene transfer therapy that delivers a transgene encoding delandistrogene moxeparvovec micro-dystrophin, an engineered, functional form of dystrophin shown to stabilize or slow disease progression in DMD. It is approved in the US and in other select countries. Two serious adverse event cases of immune-mediated myositis (IMM) were reported in the phase Ib ENDEAVOR trial (NCT04626674).
View Article and Find Full Text PDFArticle Synopsis
- - This study aimed to explore metabolic markers associated with Mycobacterium tuberculosis (M. tb) in the cerebrospinal fluid (CSF) of South African children suffering from tuberculous meningitis (TBM) using advanced metabolomics techniques.
- - Four key metabolites were found to distinguish TBM patients from controls: lower levels of mannose and arabinose, and higher levels of nonanoic acid and propanoic acid in the TBM group.
- - The research suggests that nonanoic acid may be a novel M. tb-linked marker in TBM, while propanoic acid could indicate brain energy disruptions and inflammation; however, mannose and arabinose were not effective markers for M.
Background: Outcome measurement is essential to progress clinical practice and improve patient care.
Aim: To develop a Core Outcome Set for best care for the dying person.
Design: We followed the Core Outcome Measures in Effectiveness Trials (COMET) Initiative guidelines, which involved identifying potential outcomes via a systematic literature review (n = 619 papers) and from participants in the "iLIVE" project (10 countries: 101 patients, 37 family members, 63 clinicians), followed by a two-round Delphi study, and a consensus meeting.