Immunosuppressant drug tacrolimus inhibits HUVEC angiogenesis and production of placental growth factor.

Background: Tacrolimus is a cornerstone of immunosuppression in solid organ transplants, but its use is linked with the development of endothelial dysfunction. Pregnant solid organ transplant recipients are four to six times more likely to develop preeclampsia, which is also associated with endothelial dysfunction. Therefore, this in vitro study investigated the acute effects of tacrolimus on the expression of common angiogenic factors related to preeclampsia, and effects on angiogeneis in primary human tissues.

Proteomic analysis of the subsp. SS14 strain: coverage and comparison with the Nichols strain proteome.

Introduction: Strains of the syphilis spirochete, ssp. , group into one of two deep-branching clades: the Nichols clade or the globally dominant Street Strain 14 (SS14) clade. To date, in-depth proteome-wide analyses have focused on Nichols clade strains.

No Effect of Individualized Sodium Bicarbonate Supplementation on 200-m or 400-m Freestyle-Swimming Time-Trial Performance in Well-Trained Athletes.

Purpose: This study investigated the effect of an individualized sodium bicarbonate (SB) supplementation-timing strategy on 200-m and 400-m freestyle swimming time-trial (TT) performance.

Methods: Thirteen well-trained swimmers (8 men and 5 women; mean [SD] 22 [3] y, 1.76 [0.

MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686.

Taking the structural information into account, we were able to tune the TEAD selectivity for a specific chemotype. However, different TEAD selectivity profiles did not affect the compound potency or efficacy in the NCI-H226 viability assay. Amides based on or analogues showed improved viability efficacy compared with the corresponding acids.

Physical Frailty and Functional Status in Kidney Transplantation: A Systematic Review.

Background: Frailty and functional decline are being recognized as important conditions in kidney transplant candidates. However, the ideal measures of functional status and frailty remain unknown as there is not a complete understanding of the relationship between these conditions and important post-transplant outcomes.

Objective: The objective was to examine the association between different measures of frailty and functional status evaluated before or at the time of transplant with adverse clinical outcomes post-transplantation.