Long-Term Clinical Outcomes Associated With the Veterans Health Administration's Traumatic Brain Injury and Mental Health Screens.

Objective: Examine if the mandated Veterans Affairs traumatic brain injury (TBI) screen is associated with long-term postconcussive symptoms as compared to how the mandated mental health (MH) screen is associated with long-term MH symptoms.

Setting: Veterans Health Administration.

Participants: Patients (N = 1628) who were previously screened for TBI with current postconcussive symptoms and MH conditions completed a survey assessing current postconcussive symptoms, depression, posttraumatic stress disorder, alcohol use, and physical and emotional well-being.

Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.

Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to achieve accelerated responsiveness is unclear. We found that Delta-like1 (Dll1) Notch ligands in splenic fibroblasts regulated MZB cell pool size, migration, and function.

Influence of conduction heterogeneities on transient spatiotemporal chaos in cardiac excitable media.

Life-threatening cardiac arrhythmias such as ventricular fibrillation are often based on chaotic spiral or scroll wave dynamics which can be self-terminating. In this work, we investigate the influence of conduction heterogeneities on the duration of such chaotic transients in generic models of excitable cardiac media. We observe that low and medium densities of heterogeneities extend the average transient lifetime, while at high densities very long transients, potentially persistent chaos, and periodic attractors occur.

Unusual metallic state in superconducting A15-type LaH.

Hydride superconductors continue to fascinate the communities of condensed matter physics and material scientists because they host the promising near room-temperature superconductivity. Current research has concentrated on the new hydride superconductors with the enhancement of the superconducting transition temperature ( ). The multiple extreme conditions (high pressure/temperature and magnetic field) will introduce new insights into hydride superconductors.

Targeting mitochondrial metabolism with CPI-613 in chemoresistant ovarian tumors.

Background: There is evidence indicating that chemoresistance in tumor cells is mediated by the reconfiguration of the tricarboxylic acid cycle, leading to heightened mitochondrial activity and oxidative phosphorylation (OXPHOS). Previously, we have shown that ovarian cancer cells that are resistant to chemotherapy display increased OXPHOS, mitochondrial function, and metabolic flexibility. To exploit this weakness in chemoresistant ovarian cancer cells, we examined the effectiveness of the mitochondrial inhibitor CPI-613 in treating preclinical ovarian cancer.