Fetal Cartilage Progenitor Cells in the Repair of Osteochondral Defects.

Background: Therapies for cartilage restoration are of great interest, but current options provide limited results. In salamanders, interzone (IZN) tissue can regenerate large joint lesions. The mammalian homolog to this tissue exists during fetal development and exhibits remarkable chondrogenesis in vitro.

Training and peer-group coaching for pairs of researchers and patient representatives to support continuous two-way learning.

Background: Patient involvement is most common during the first phases of a research project. Despite good intentions, maintaining meaningful collaborations throughout the research process doesn't seem easy. Several training programmes for researchers and patients have been developed to stimulate continuous involvement.

The interaction between seminal plasma, sperm, and endometrium in inter- and intra-species breeding in equids.

In Brief: In some instances, extra-species breeding in equids is more successful than intraspecies breeding; however, little is known about the immunomodulatory effect of donkey semen and seminal plasma on the mare's endometrium. This study compared the mare uterine inflammatory response during extra- and intraspecies breeding.

Abstract: Anecdotal experience suggests horse mares have less post-breeding inflammation and better fertility when bred with donkeys.

Sales and race performance of juvenile Thoroughbreds with surgically corrected large colon displacements.

Background: Juvenile Thoroughbreds can be expensive to raise and train to race. Part of the economic return in these juveniles are the weanling, yearling and 2-year-old in training sales at which major surgeries must be declared.

Objectives: To determine if surgically corrected large colon displacements were associated with a reduction of sales price and racing performance.

Single-nuclei analysis reveals depot-specific transcriptional heterogeneity and depot-specific cell types in adipose tissue of dairy cows.

Adipose tissue (AT) is an endocrine organ with a central role on whole-body energy metabolism and development of metabolic diseases. Single-cell and single-nuclei RNA sequencing (scRNA-seq and snRNA-seq, respectively) analyses in mice and human AT have revealed vast cell heterogeneity and functionally distinct subtypes that are potential therapeutic targets to metabolic disease. In periparturient dairy cows, AT goes through intensive remodeling and its dysfunction is associated with metabolic disease pathogenesis and decreased productive performance.