Publications by authors named "S L London"
Introduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm.
View Article and Find Full Text PDFThe Europa Imaging System (EIS) consists of a Narrow-Angle Camera (NAC) and a Wide-Angle Camera (WAC) that are designed to work together to address high-priority science objectives regarding Europa's geology, composition, and the nature of its ice shell. EIS accommodates variable geometry and illumination during rapid, low-altitude flybys with both framing and pushbroom imaging capability using rapid-readout, 8-megapixel (4k × 2k) detectors. Color observations are acquired using pushbroom imaging with up to six broadband filters.
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- - Children born via cesarean delivery have a greater risk of various health issues compared to those born vaginally, but the exact reasons are still not fully understood.
- - A meta-analysis involving over 12,000 participants found six specific DNA methylation markers in newborns linked to cesarean delivery, but these markers did not persist into childhood.
- - The study indicates that cesarean delivery affects certain blood cell proportions at birth, but further research is necessary to understand its long-term impacts on child health.
Article Synopsis
- This study investigates the link between an epigenetic risk score (ERS) related to alcohol consumption and blood pressure traits, finding significant associations between higher ERS and increased blood pressure levels among participants.
- In the analysis of 3,898 individuals from the Framingham Heart Study, each unit increase in the ERS correlated with a rise in systolic blood pressure (SBP) by almost 2 mm Hg and diastolic blood pressure (DBP) by about 0.68 mm Hg.
- The research suggests that the ERS could serve as a useful tool for assessing cardiovascular risks linked to alcohol consumption, especially in cases where self-reported data may be unreliable.
Article Synopsis
- Low maternal vitamin D levels during pregnancy have been linked to various health issues in offspring and may affect DNA methylation, a process that influences gene expression.
- The study examined the relationship between maternal vitamin D insufficiency (defined as less than 75 nmol/L) and DNA methylation patterns in the cord blood of newborns using data from 3738 mother-child pairs across seven cohorts.
- Despite a significant prevalence of vitamin D insufficiency among the mothers (ranging from 44.3% to 78.5%), the research found no significant association between maternal vitamin D levels and DNA methylation at the analyzed sites after adjusting for various factors.