Publications by authors named "S L Lightman"
Purpose: Evaluation of longer-term effectiveness of three intravitreal therapies (methotrexate, ranibizumab, or dexamethasone implant) for participants enrolled in the randomized comparative effectiveness trial the Macular Edema Ranibizumab versus Intravitreal anti-inflammatory Therapy (MERIT) Trial followed for24 weeks.
Design: Multicenter randomized controlled clinical trial with masked evaluation of retinal thickness and visual acuity.
Participants: Patients with persistent or recurrent uveitic macular edema.
Article Synopsis
- - Mineralocorticoid (MR) and glucocorticoid receptors (GR) are key transcription factors involved in various processes like stress response, hormonal signalling, mood, cognition, and memory, despite their structural differences, especially in the N-terminal domain.
- - A study using a Proximity Ligation Assay (PLA) on murine neuroblastoma (N2A) cells showed that continuous stimulation with corticosterone (CORT) results in MR-GR complexes accumulating at the cell nucleus's periphery, particularly when the receptor's ligand binding domain is truncated.
- - Interestingly, while MR-GR complex localization changed with receptor activation, there wasn't a straightforward link between where these complexes were located in the nucleus and
Aims: To determine the impact of microorganism virulence on visual outcomes in endophthalmitis.
Methods: Retrospective, multicentre cohort study of patients presenting with endophthalmitis between 2006 and 2021. A literature review was conducted to divide cultured microorganisms into low and high virulence subcategories.
Selye described stress as a unified neurohormonal mechanism maintaining homeostasis. Acute stress system activation is adaptive through neurocognitive, catecholaminergic, and immunomodulation mechanisms, followed by a reset via cortisol. Stress system components, the sympathoadrenomedullary system, hypothalamic-pituitary-adrenal axis, and limbic structures are implicated in many chronic diseases by establishing an altered homeostatic state, allostasis.
View Article and Find Full Text PDFThe hypothalamic-pituitary-adrenal axis is an extremely dynamic system with a combination of both circadian and ultradian oscillations. This state of 'continuous dynamic equilibration' provides a platform that is able to anticipate events, is sensitive in its response to stressors, remains robust during perturbations of both the internal and external environments and shows plasticity to adapt to a changed environment. In this review, we describe these oscillations of glucocorticoid (GC) hormones and why they are so important for GC-dependent gene activation in the brain and liver, and their consequent effects on the regulation of synaptic and memory function as well as appetite control and metabolic regulation.
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