Analysing the performance of low-cost air quality sensors, their drivers, relative benefits and calibration in cities-a case study in Sheffield.

Traditional real-time air quality monitoring instruments are expensive to install and maintain; therefore, such existing air quality monitoring networks are sparsely deployed and lack the measurement density to develop high-resolution spatiotemporal air pollutant maps. More recently, low-cost sensors have been used to collect high-resolution spatial and temporal air pollution data in real-time. In this paper, for the first time, Envirowatch E-MOTEs are employed for air quality monitoring as a case study in Sheffield.

Cardiac Resynchronization Therapy Delivered Via a Multipolar Left Ventricular Lead is Associated with Reduced Mortality and Elimination of Phrenic Nerve Stimulation: Long-Term Follow-Up from a Multicenter Registry.

Introduction: Cardiac resynchronization therapy (CRT) using quadripolar left ventricular (LV) leads provides more pacing vectors compared to bipolar leads. This may avoid phrenic nerve stimulation (PNS) and allow optimal lead placement to maximize biventricular pacing. However, a long-term improvement in patient outcome has yet to be demonstrated.

Relating oxygen demand to flow: development of an in situ sediment oxygen demand measurement device.

This paper describes the continuation of an investigation into the effects of increased flow on the dissolved oxygen concentration in the River Maun, UK. A previous investigation indicated that an oxygen demand additional to that in the water phase is observed during and directly after intermittent discharges. Simplified modelling of the river indicated that the additional oxygen demand was possibly linked to the disturbance of sediment during such events.

Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.

Although the platelets of the mouse are refractory to the direct effects of platelet-activating-factor (PAF), tail vein injection of 10-150 micrograms/kg PAF produces lethal anaphylactic shock. Sensitivity varies with strain and source: Swiss Webster mice show a range of sensitivity and DBA/2 (complement C5-deficient) mice are very resistant. At lethal doses of PAF, animals show labored respiration and general depression; death occurs within 15-45 min.

Divergent effects of suramin on in vitro and in vivo assays of cartilage degradation.

Proteinases are thought to be responsible for cartilage and bone erosion noted in chronic inflammatory conditions. Suramin [8-(3-benzamindo-4-meta-1-benzamindo)naphthalene-1,3,5-trisulfonic acid], 10(-5) and 10(-4) M, inhibited the release of a mouse macrophage-derived cartilage proteoglycan-degrading enzyme. At 10(-5) M it antagonized the activity of beta-glucuronidase and cathepsin D derived from the mouse macrophage, as well as similar enzymes secreted by rat macrophages in vivo.