Effects of exercise training on nigrostriatal neuroprotection in Parkinson's disease: a systematic review.

Introduction: Parkinson's disease (PD) is characterized by progressive neurodegeneration within the nigrostriatum, leading to motor dysfunction. This systematic review aimed to summarize the effects of various exercise training regimens on protein or gene expression within the nigrostriatum and their role in neuroprotection and motor function improvement in animal models of Parkinson's disease (PD).

Methods: PubMed, EMBASE, and Web of Science were searched up to June 2024 and included sixteen studies that adhere to PRISMA guidelines and CAMARADES checklist scores ranging from 4 to 6 out of 10.

Effects of Exercise Training on Cardiac Mitochondrial Functions in Diabetic Heart: A Systematic Review.

A diabetic heart is characterized by fibrosis, autophagy, oxidative stress, and altered mitochondrial functions. For this review, three databases (PubMed, EMBASE, and Web of Science) were searched for articles written in English from September 2023 to April 2024. Studies that used exercise training for at least 3 weeks and which reported positive, negative, or no effects were included.

Primary Amenorrhea in a 15-Year-Old Girl Leading to the Diagnosis of Bardet-Biedl Syndrome: A Case Report.

This case report highlights the clinical complexity of Bardet-Biedl syndrome, a rare autosomal recessive disorder, emphasizing reproductive anomalies to aid in diagnosis and management. It underscores the importance of thorough assessment and advocates for genetic testing to optimize care, despite current financial, and laboratory constraints.

Spontaneous Tumor Lysis Syndrome in the Setting of Pancreatic Adenocarcinoma.

Tumor lysis syndrome (TLS) is the destruction of tumor cells, causing the release of intracellular contents, including but not limited to uric acid, phosphate, and potassium. This can manifest with significant physiologic abnormalities, such as life-threatening acute kidney injury. Although TLS is usually caused by the initiation of cytotoxic chemotherapy, it may also occur spontaneously, particularly in high-grade malignancies with high tumor burden and/or rapid cell turnover.

Queer- and trans-inclusive faculty hiring-A call for change.

As queer and trans scientists, we face varied and systemic barriers to our professional success, resulting in our relative absence from faculty ranks at many institutions. In this Perspective, we call for a change in faculty hiring practices and present concrete guidance to make it a more inclusive process.