Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants.

Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds are generated by oxidosqualene cyclases, which carry out a polycyclization cascade to generate four or five rings with up to nine stereogenic centers in a targeted manner. The tight stereochemical control of this cascade reaction severely limits the stereochemical space accessible by known oxidosqualene cyclases.

Digital Transformation During the Pandemic: Lessons from BRAC Health Program's Experience in Bangladesh.

The COVID-19 pandemic accelerated digital transformation in public health and development organizations worldwide such as BRAC Health Program (BHP). Key success factors included early adoption of digital collaboration tools, systematic workforce training, and a phased implementation approach. The experiences of BHP offer insights that can be insightful for other nations.

Macrophages protect against sensory axon loss in peripheral neuropathy.

Peripheral neuropathy is a common complication of type 2 diabetes, which is strongly associated with obesity, causing sensory loss and, in some patients, neuropathic pain. Although the onset and progression of diabetic peripheral neuropathy is linked with dyslipidaemia and hyperglycaemia, the contribution of inflammation to peripheral neuropathy pathogenesis has not been investigated. Here we used a high-fat, high-fructose diet (HFHFD), which induces obesity and prediabetic metabolic changes, to study the onset of peripheral neuropathy.

hsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family.

Introduction: Flaviviridae comprise a group of enveloped, positive-stranded RNA viruses that are mainly transmitted through either mosquitoes or tick bites and/or contaminated blood, blood products, or other body secretions. These viruses cause diseases ranging from mild to severe and are considered important human pathogens. MicroRNAs (miRNAs) are non-coding molecules involved in growth, development, cell proliferation, protein synthesis, apoptosis, and pathogenesis.

Diversity and functional traits based indigenous rhizosphere associated phosphate solubilizing bacteria for sustainable production of rice.

Introduction: Rice, particularly Basmati rice, holds significant global importance as a staple food. The indiscriminate use of phosphate-based fertilizers during rice production has led to high residual levels of these chemicals in soil, impacting soil health and fertility. This study aimed to address this challenge by investigating the potential of phosphate solubilizing bacteria (PSB) in improving soil fertility and boosting the growth of Basmati rice.