Publications by authors named "S L Gudmundsdottir"
Background: Signal transducer and activator of transcription 6 (STAT6) is central to type 2 (T2) inflammation, and common noncoding variants at the STAT6 locus associate with various T2 inflammatory traits, including diseases, and its pathway is widely targeted in asthma treatment.
Objective: We sought to test the association of a rare missense variant in STAT6, p.L406P, with T2 inflammatory traits, including the risk of asthma and allergic diseases, and to characterize its functional consequences in cell culture.
Article Synopsis
- Immunoglobulin G (IgG) is the primary type of antibody in human blood and exists in four subclasses (IgG1 to IgG4), which are influenced by specific genes.
- A genome-wide association study involving 4,334 adults and 4,571 children identified ten new variants and confirmed four known variants linked to IgG subclass levels, affecting conditions like asthma and autoimmune diseases.
- Significant links were found between certain genetic allotypes and specific IgG subclasses, with notable findings showing that lower IgG4 levels can both protect against childhood asthma and increase the risk of inflammatory bowel disease.
Problematic low energy availability (LEA) is the underlying cause of relative energy deficiency in sport (REDs). Male specific etiology, as well as the duration and degree of LEA exposures resulting in REDs remain to be adequately described. The present study aimed to assess occurrences of LEA (energy availability [EA] <25 kcal/kg fat-free mass/day) in male athletes from various sports over 7 days.
View Article and Find Full Text PDFBackground: Problematic low energy availability (EA) is the underlying culprit of relative energy deficiency in sport (REDs), and its consequences have been suggested to be exacerbated when accompanied by low carbohydrate (CHO) intakes.
Objectives: This study compared dietary intake, nutrition status and occurrence of REDs symptoms in groups of female athletes, displaying different patterns of EA and CHO intake.
Methods: Female athletes ( = 41, median age 20.
Article Synopsis
- Sedentary behavior (SB), or prolonged sitting, has been linked to various health issues, particularly regarding bone health, but there is a lack of population-based data on its long-term impact on bone density and fracture risk.
- The study assessed the relationship between daily sitting time, bone mineral density (BMD) measured via DXA, and the incidence of low-trauma fractures in a diverse group of over 8,000 participants in Canada aged 25 to 80+.
- The findings indicated that while increased SB was associated with lower baseline BMD in certain groups, it did not correlate with significant changes in BMD or an increased risk of fractures over a 10-year period.