Publications by authors named "S L Gottlieb"
Background: Globally, herpes simplex virus (HSV)-2 and -1 infections contribute to a large disease burden, but their full economic consequences remain unclear. This study aims to estimate the global economic impact of genital HSV-2 and HSV-1 infection and its consequences for people with genital ulcer disease, neonatal herpes, and human immunodeficiency virus (HIV) infection attributable to HSV-2.
Methods: Using a societal perspective, the economic burden was calculated at the country level and presented by World Health Organization (WHO) regions and World-Bank income levels.
Objectives: Genital herpes simplex virus (HSV) type 1 and 2 infections are lifelong and can cause symptomatic genital ulcer disease (GUD). HSV-2 almost always causes sexually transmitted genital infection, while HSV-1 mainly causes oral infection but can be sexually transmitted to cause genital infection. This study estimated genital infection with both HSV types and associated GUD globally in 2020, breaking down the data by WHO region and sex for females and males.
View Article and Find Full Text PDFBackground: Clinical genetic evaluation of dilated cardiomyopathy (DCM) is implemented variably or not at all. Identifying needs and barriers to genetic evaluations will enable strategies to enhance precision medicine care.
Methods: An online survey was conducted in June 2024 among cardiologist investigators of the DCM Consortium from US advanced heart failure/transplant (HF/TX) programs to collect demographics, training, program characteristics, genetic evaluation practices for DCM, and implementation needs.
Article Synopsis
- Increasing biological nitrogen fixation (BNF) in maize can lessen the environmental harm caused by synthetic nitrogen fertilizers, but high levels of reactive nitrogen in the rhizosphere hinder this process.
- Researchers developed gene-edited strains of bacteria (Klebsiella variicola and Kosakonia sacchari) to enhance BNF and ammonium release in nitrogen-rich conditions.
- Experiments showed that these engineered strains significantly boosted BNF activity and ammonium output, contributing an average of 21 kg of nitrogen per hectare to maize plants, thus potentially reducing reliance on synthetic fertilizers and improving crop yield stability.
AMBRA1 controls the translation of immune-specific genes in T lymphocytes.
Proc Natl Acad Sci U S A
October 2024
T cell receptor (TCR) engagement causes a global cellular response that entrains signaling pathways, cell cycle regulation, and cell death. The molecular regulation of mRNA translation in these processes is poorly understood. Using a whole-genome CRISPR screen for regulators of CD95 (FAS/APO-1)-mediated T cell death, we identified AMBRA1, a protein previously studied for its roles in autophagy, E3 ubiquitin ligase activity, and cyclin regulation.
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