Clinical Course of Isolated Recurrent, Persistent Complex Perianal Fistulas Without Luminal Crohn's Disease: A Multicenter Case Series of 24 Patients.

Background: Isolated complex perianal fistulas, without luminal evidence of inflammatory bowel disease in the gastrointestinal tract, pose diagnostic and treatment dilemmas for gastroenterologists and colorectal surgeons. For patients who develop recurrent complex fistulas, a presumptive diagnosis of Crohn's disease may be made. It is unclear whether these cases of isolated perianal disease in the absence of luminal inflammation truly represent isolated severe cryptoglandular fistulas or rather an early presentation of Crohn's disease.

Associations between weather and malaria in an elimination setting in Peru: a distributed lag analysis.

Background: () is the predominant malaria species in countries approaching elimination. In the context of climate change, understanding environmental drivers of transmission can guide interventions, yet evidence is limited, particularly in Latin America.

Objectives: We estimated the association between temperature and precipitation and malaria incidence in a malaria elimination setting in Peru.

Understanding Trajectories of Generalized Anxiety Disorder Among Adolescents During the COVID-19 Pandemic: Evidence From China and the Democratic Republic of the Congo.

Purpose: This study aims to assess anxiety trends over the COVID-19 pandemic and evaluate how pandemic-related adversities modify trajectories among underprivileged adolescents from two distinct settings.

Methods: Data came from the Shanghai, China and Kinshasa, Democratic Republic of the Congo sites of the Global Early Adolescent Study. Data were collected three times over approximately two years: prior to the pandemic (T1) and during the pandemic (T2, T3).