Publications by authors named "S L Emanuel"
Background: Chronic kidney disease (CKD) and atrial fibrillation (AF) are increasing in prevalence globally and share common risk factors.Our aim was to characterise real-world evidence on direct oral anticoagulant (DOAC) prescribing for people with AF and CKD, in terms of adherence, persistence and renal dose titration.
Methods: PubMed, EMBASE and CINAHL were searched from inception to June 2022.
Article Synopsis
- In England, a study analyzed trends in prescribing direct oral anticoagulants (DOACs) for atrial fibrillation (AF) using data from 722 general practices between 2014 and 2019, aiming to identify proper dosing and adherence issues.
- The results showed improved appropriate prescribing of DOACs based on kidney function, with significant increases in adherence rates, particularly for factor Xa inhibitors.
- The findings also indicated disparities in adherence among different ethnic groups, socioeconomic statuses, and genders, suggesting that future efforts should focus on addressing these gaps in anticoagulant management.
Introduction: The discontinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS) is commonly seen in real-world settings due to several factors.
Area Cover: The aim of this study is to describe the frequency of disease activity after discontinuation of DMTs in MS patients included in the Argentinean MS and NMOSD registry.
Discusion: Patients with relapsing remitting MS (RRMS) and active secondary progressive MS (SPMS) were included based on the following criteria: they discontinued treatment for more than 6 months, they had been treated with a DMT for ≥2 years, and they had at least 6 months of follow-up in the registry after discontinuation.
Mild Positive Pressure Improves the Efficacy of Benzalkonium Chloride against Biofilm.
Bioengineering (Basel)
September 2022
Current protocols using liquid disinfectants to disinfect heat-sensitive hospital items frequently fail, as evidenced by the continued isolation of bacteria following decontamination. The contamination is, in part, due to biofilm formation. We hypothesize that mild positive pressure (PP) will disrupt this biofilm structure and improve liquid disinfectant/detergent penetration to biofilm bacteria for improved killing.
View Article and Find Full Text PDFThe parasitoid wasp envenomates the brain of its host the American cockroach (), thereby making it a behaviorally compliant food supply for its offspring. The target of venom injection is a locomotory command center in the brain called the central complex. In this study, we investigate why stung cockroaches do not respond to injuries incurred during the manipulation process by the wasp.
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