Publications by authors named "S L Cottingham"

Article Synopsis
  • Despite extensive research on genomic changes in glioblastoma, the survival rate remains under 5% after five years.
  • This study aims to broaden the understanding of high-grade glioma by combining various biological analyses (proteomics, metabolomics, etc.) to identify complex regulatory mechanisms involved in tumor growth and progression.
  • Results from analysis of 228 tumors indicate significant variability in early-stage changes, but they converge on common outcomes affecting protein interactions and modifications, highlighting PTPN11's crucial role in high-grade gliomas.
View Article and Find Full Text PDF

A 7-year-old farmed white-tailed deer doe was transported to a Levy County, Florida property and began to decline in health, exhibiting weight loss and pelvic limb weakness. The doe prematurely delivered live twin fawns, both of which later died. The doe was treated with corticosteroids, antibiotics, gastric cytoprotectants, and B vitamins but showed no improvement.

View Article and Find Full Text PDF

Plastic debris widely pollutes freshwaters. Abiotic and biotic degradation of plastics releases carbon-based substrates that are available for heterotrophic growth, but little is known about how these novel organic compounds influence microbial metabolism. Here we found leachate from plastic shopping bags was chemically distinct and more bioavailable than natural organic matter from 29 Scandinavian lakes.

View Article and Find Full Text PDF

Pollution from microplastics and anthropogenic fibres threatens lakes, but we know little about what factors predict its accumulation. Lakes may be especially contaminated because of long water retention times and proximity to pollution sources. Here, we surveyed anthropogenic microparticles, i.

View Article and Find Full Text PDF

Hemorrhagic disease (HD) caused by bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) is the most important viral disease of farmed and wild white-tailed deer (WTD; ) and can cause substantial mortality in susceptible hosts. Captive cervid farming is an emerging industry in Florida, an HD-enzootic region. Morbidity and mortality due to HD are major concerns among deer farmers, but the impact of HD on Florida's cervid farming industry is unknown.

View Article and Find Full Text PDF