Publications by authors named "S L Chudorodova"
Article Synopsis
- mXin alpha is a protein important for heart function, and its absence leads to significant reductions in potassium and calcium currents in heart cells, causing increased risk of arrhythmias.
- The study measured changes in sodium currents and how fast electrical signals move in heart tissue, finding a 36% reduction in conduction velocity in mXin alpha-deficient hearts.
- Results showed that while conduction speed slowed, sodium and transient inward currents increased in these defective heart cells, contributing to arrhythmias; cooling the heart reduced these disturbances.
Objective: The purpose of this research was to study the propagation of the excitation wave along epicardium in the area of the pulmonary veins ostia in rabbit in normal conditions and while cooling.
Methods: The excitation wave spreading along epicardium in the area of pulmonary veins ostia in the left atrium at 36-37 degrees C and when cooling to 32 degrees C was studied by the method of electrocardiochronotopography in rabbit of Chinchilla species, five months age. The size of the registering surface of the electrode was 1.
The form and distribution of extracellular cardioelectric potentials and the sequence of the excitation wave propagation on epicardium of the pig atria were studied by the method of multichannel synchronous cardioelectrotopography. The studies have shown that in pig the excitation wave breaks on epicardium of the right atrium at the base of the upper vena cava. Negative initial atrial complexes are registered in this area.
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